Zotatifin

Zotatifin,eFT226, is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.


Cat. No.: EX-A4623	Purity: >98%

	Chemical structure of Zotatifin

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1mg	785	Inquire
2mg	1200	Inquire
5mg	1950	Inquire
10mg	3200	In-stock

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Synonyms	eFT226
CAS No.	2098191-53-6
Purity	>98%
Formula	C28H29N3O5
Mol Weight	487.547
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

CoA	CoA of Zotatifin

Smiles:	N#CC1=CC=C([C@@]2(O3)[C@@](C4=C3C=C(OC)N=C4OC)(O)[C@H](O)[C@H](CN(C)C)[C@H]2C5=CC=CC=C5)C=C1


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